Cause
Type 1 diabetes develops because the body's defense
system (immune system) tells the body to destroy the beta
cells in the pancreas that make
insulin. It's not known what causes this immune
response. Some people inherit the risk for type 1 diabetes. However, even these
people may not develop type 1 diabetes unless other factors, such as exposure
to certain viral infections, are present.
- In infants and children, the beta cells usually
are destroyed rapidly, resulting in a sudden rise in blood sugar level and a
sudden onset of diabetes symptoms.
- In adults, the cells often are
destroyed more slowly, resulting in a slower rise in blood sugar level and a
slower onset of diabetes symptoms.
Certain
genes make a person more susceptible while other genes
seem to protect the person from the disease. A complex interaction between a
person's genes and some environmental factors, such as having
enteroviral infections—especially Coxsackie B
infections—may increase the risk of developing the disease, but it does not
mean that the person will definitely develop the disease.
In the past, experts thought that vaccines caused diabetes. But
studies have found no link between getting a vaccination and getting type 1
diabetes.2